R-454B

Sources disagree

More than one authority states this, and they do not state the same thing. Both are reproduced with the source each came from — deciding between them is yours, not ours.

Trade name(s)

epa.gov says trade name(s) is Opteon™ XL41, as of 2026-08-11.

R-454B | Opteon™ XL41 | N | 0 | 470 | A2L | <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. |

https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps

prod-edam.honeywell.com says trade name(s) is Solstice® 454B, as of 2026-08-11.

Solstice® 454B (R-454B) is a mildly flammable (A2L) stricter A2 usage requirements. refrigerant having a boiling point of -58.1o F (average of dew and bubble) at 0 psig. R-454B will primarily be used for air Within ASHRAE there are many ways in which an A2L conditioning and reversible heating systems, especially in refrigerant such as R-454B can be utilized. A few are residential and light commercial applications. highlighted below (see ASHRAE 15 for full details): The environmental properties of Solstice® 454B (R-454B) • Self-contained commercial occupancy, refrigerant include a zero Ozone Depletion Potential (ODP) and a GWP of charge < 22lb 467 (AR5).

https://prod-edam.honeywell.com/content/dam/honeywell-edam/pmt/oneam/en-us/refrigerants/documents/pmt-am-solstice-454b-applications-guide.pdf

GWP

epa.gov says gwp is 470, as of 2026-08-11.

R-454B | Opteon™ XL41 | N | 0 | 470 | A2L | <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. |

https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps

prod-edam.honeywell.com says gwp is 467 (AR5), as of 2026-08-11.

Solstice® 454B (R-454B) is a mildly flammable (A2L) stricter A2 usage requirements. refrigerant having a boiling point of -58.1o F (average of dew and bubble) at 0 psig. R-454B will primarily be used for air Within ASHRAE there are many ways in which an A2L conditioning and reversible heating systems, especially in refrigerant such as R-454B can be utilized. A few are residential and light commercial applications. highlighted below (see ASHRAE 15 for full details): The environmental properties of Solstice® 454B (R-454B) • Self-contained commercial occupancy, refrigerant include a zero Ozone Depletion Potential (ODP) and a GWP of charge < 22lb 467 (AR5).

https://prod-edam.honeywell.com/content/dam/honeywell-edam/pmt/oneam/en-us/refrigerants/documents/pmt-am-solstice-454b-applications-guide.pdf

Listing status / notes

epa.gov says listing status / notes is Acceptable with Use Conditions: See rule for detailed conditions., as of 2026-08-11.

R-454B | Opteon™ XL41 | N | 0 | 470 | A2L | <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. |

https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps

trane.com says listing status / notes is do not permit mixing and matching any components designed for an A1 refrigerant, as of 2026-08-11.

than R-454B will need to be upgraded. As of this document, current building codes and EPA regulations do not permit mixing and matching any components designed for an A1 refrigerant, such as R-410A with any components designed for an A2L refrigerant such as R-454B. This includes air handling unit components. Should the installer replace any A1 system with one containing A2Ls, the installer must also confirm that all connected refrigerant piping and and refrigerant specialties are also certified and listed for use with the specific A2L refrigerant. Failure to do so will create a hazardous and unsafe condition. Every part of an existing split system needs to be analyzed to determine if it can be reused in an R-454B and POE oil system:

https://www.trane.com/content/dam/Trane/Commercial/global/products-systems/equipment/unitary/split-systems/rauj-cauj-20-to-120-tons/SS-APG018A-EN_11102024.pdf