Which refrigerant substitutes for which in air conditioning, heat pump and refrigeration equipment, drawn from the EPA SNAP substitutes list, compressor-manufacturer bulletins (Copeland) and refrigerant-manufacturer replacement guides (Chemours, Honeywell, Arkema). Each record carries the ASHRAE safety classification, GWP, whether the substitute is approved for retrofit or new equipment only, and the compatible lubricant. Answers 'can I put R-454B in an R-410A system', 'what replaces R-22 without changing the oil', and 'is this substitute EPA-acceptable' — questions where the wrong answer damages equipment or breaks federal rules.

Factual compilation with source citations. EPA SNAP substitute listings are US government work (public domain). Manufacturer figures (Copeland, Chemours, Honeywell, Trane, Arkema) are facts taken with short attributed quotes linking back to the published guide.

HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** Ammonia Absorption

**Retrofit / new:** N

**ASHRAE safety class:** B2

**GWP:** 0

**Listing status / notes:** Acceptable

> Ammonia Absorption | | N | 0 | 0 | B2 | <https://www.govinfo.gov/app/details/FR-1996-09-05/96-22649> September 5, 1996 | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

Ammonia Absorption — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** CFC R-12

**GWP:** 10900

**Compatible lubricant:** MIN

**Listing status / notes:** Phased out in 1996

> CFC R-12 10900 L,M MIN AB & MIN Phased out in 1996

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

CFC R-12 — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** CFC R-502

**GWP:** 4657

**Compatible lubricant:** MIN

**Listing status / notes:** Phased out in 1996

> CFC R-502 4657 L,M MIN AB & MIN POE-32 Phased out in 1996

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

CFC R-502 — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** Desiccant Cooling

**Retrofit / new:** N

**GWP:** N/A

**Listing status / notes:** Acceptable

> Desiccant Cooling | | N | 0 | N/A | N/A | <https://www.govinfo.gov/app/details/FR-1996-09-05/96-22649> September 5, 1996 ; <https://www.govinfo.gov/content/pkg/FR-2010-06-16/pdf/2010-14510.pdf> June 16, 2010 (pdf) (229 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

Desiccant Cooling — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** Evaporative Cooling

**Retrofit / new:** N

**GWP:** N/A

**Listing status / notes:** Acceptable

> Evaporative Cooling | | N | 0 | N/A | N/A | <https://www.govinfo.gov/app/details/FR-1996-09-05/96-22649> September 5, 1996 | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

Evaporative Cooling — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HCFC R-22

**GWP:** 1810

**Compatible lubricant:** MIN

**Listing status / notes:** No new equipment 2010**

> HCFC R-22 1810 L,M,H MIN AB & MIN POE-32 No new equipment 2010**

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HCFC R-22 — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HCR 4141

**Listing status / notes:** acceptable, subject to use conditions

> The EPA is proposing to list HCR 4141, HFO-1234ze(E), and R-516A as acceptable, subject to use conditions, for this end-use. HCR 4141 is a higher flammability refrigerant blend with each component in the A3 Safety Group. HFO-1234ze(E) and R-516A are lower flammability refrigerants, both in the A2L Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

HCR 4141 — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HFC-134a

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 1,430

**Listing status / notes:** Acceptable

> HFC-134a | | R/N | 0 | 1,430 | A1 | <https://www.govinfo.gov/content/pkg/FR-2010-06-16/pdf/2010-14510.pdf> June 16, 2010 (pdf) (229 KB); <https://www.govinfo.gov/content/pkg/FR-2017-07-21/pdf/2017-15379.pdf> July 21, 2017 (pdf) (314 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

HFC-134a — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HFC-32

**ASHRAE safety class:** A2L

> Using these safety groups, HFO-1234ze(E), HFC-32 and the refrigerant blends R-452B, R-454A, R-454B, R-454C, R-457A, and R-516A are in the A2L Safety Group, while R-290, R-441A, and the components of HCR 4141 are in the A3 Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

HFC-32 — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HFC-32

**Retrofit / new:** N

**ASHRAE safety class:** A2L

**GWP:** 675

**Listing status / notes:** Acceptable with Use Conditions: See rules for detailed conditions.

> HFC-32 | | N | 0 | 675 | A2L | <https://www.govinfo.gov/content/pkg/FR-2015-04-10/pdf/2015-07895.pdf> April 10, 2015 (pdf) (769 KB); <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB); <https://www.govinfo.gov/content/pkg/FR-2023-04-28/pdf/2023-08663.pdf> April 28, 2023 (pdf) (584 KB) | Acceptable with Use Conditions: See rules for detailed conditions. |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>


**Refrigerant:** HFC R-134a

**GWP:** 1430

> HFC R-134a 1430 R-134a manufactured in India

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HFC R-134a — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HFO-1234yf

**Retrofit / new:** retrofit

**Listing status / notes:** acceptable, subject to use conditions

> List HFO-1234yf as acceptable, subject to use conditions, in retrofit light- and medium-duty vehicle (LMDV) motor vehicle air conditioning (MVAC), in new MVACs on buses, and in new MVACs in heavy-duty on-highway (HDOH) vehicles;

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

HFO-1234yf — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HFO-1234yf

**ASHRAE safety class:** A2L

> ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>


**Refrigerant:** HFO-1234ze(E)

**ASHRAE safety class:** A2L

**Listing status / notes:** acceptable, subject to use conditions

> The EPA is proposing to list HCR 4141, HFO-1234ze(E), and R-516A as acceptable, subject to use conditions, for this end-use. HCR 4141 is a higher flammability refrigerant blend with each component in the A3 Safety Group. HFO-1234ze(E) and R-516A are lower flammability refrigerants, both in the A2L Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

HFO-1234ze(E) — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HCFC R-401A

**Replaces:** R-12

**Trade name(s):** Freon™ MP39

**GWP:** 1182

**Compatible lubricant:** AB & MIN

**Listing status / notes:** For service applications only

> HCFC R-401A 1182 R-12 M,H AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: Freon™ MP39

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HCFC R-401A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HCFC R-401B

**Replaces:** R-12

**Trade name(s):** Freon MP66

**GWP:** 1288

**Compatible lubricant:** AB & MIN

**Listing status / notes:** For service applications only

> HCFC R-401B 1288 R-12 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: Freon MP66

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HCFC R-401B — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HCFC R-409A

**Replaces:** R-12

**Trade name(s):** FX56

**GWP:** 1909

**Compatible lubricant:** AB & MIN

**Listing status / notes:** For service applications only

> HCFC R-409A 1909 R-12 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: FX56

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HCFC R-409A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-450A

**Replaces:** R-12/R-134a

**Trade name(s):** Solstice N13

**GWP:** 601

**Compatible lubricant:** POE-32

**Listing status / notes:** Solstice N13 for refrigeration applications only

> R-12/R-134a M,H M,H POE-32 Solstice N13 for refrigeration applications only R-450A 601 R12 L,M L,M POE-22D Compressors produced in Brazil

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

R-450A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-514A

**Replaces:** R-123

**Trade name(s):** Opteon™ XP30

**ASHRAE safety class:** B1

**GWP:** 7 (2)

**Compatible lubricant:** POE

> R-123 Replacement Opteon™ XP30 R-514A B1 7 (2) POE

Source: <https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf>

R-514A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-125/R-134a/R-600a (28.1/70.0/1.9)

**Trade name(s):** NU-22 old composition

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 1,990

**Listing status / notes:** Acceptable

> R-125/R-134a/R-600a (28.1/70.0/1.9) | NU-22 old composition | R/N | 0 | 1,990 | A1 | <https://www.govinfo.gov/content/pkg/FR-2010-06-16/pdf/2010-14510.pdf> June 16, 2010 (pdf) (229 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-125/R-134a/R-600a (28.1/70.0/1.9) — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5)

**Trade name(s):** ICOR AT-22

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 2,530

**Listing status / notes:** Acceptable

> R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5) | ICOR AT-22 | R/N | 0 | 2,530 | A1 | <https://www.govinfo.gov/content/pkg/FR-2006-03-29/pdf/06-3030.pdf> March 29, 2006 (pdf) (181 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5) — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-1270 (Propylene)

**Retrofit / new:** N

**ASHRAE safety class:** A3

**GWP:** 1.8

**Listing status / notes:** Unacceptable , as of January 3, 2017.

> R-1270 (Propylene) | | N | 0 | 1.8 | A3 | <https://www.govinfo.gov/content/pkg/FR-2016-12-01/pdf/2016-25167.pdf> December 1, 2016 (pdf) (969 KB) | Unacceptable , as of January 3, 2017. |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-1270 (Propylene) — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-1234yf

**Replaces:** R-134a

**Trade name(s):** Opteon™ XL10

**ASHRAE safety class:** A2L

**GWP:** 4 (1)

> Opteon™ XP10 R-513A R-134a A1 631 (573) -21 Opteon™ XL10 R-1234yf R-134a A2L 4 (1) -21

Source: <https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf>

R-1234yf — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-513A

**Replaces:** R-134a

**Trade name(s):** Opteon™ XP10

**ASHRAE safety class:** A1

**GWP:** 631 (573)

**Compatible lubricant:** POE

> R-134a Replacement for Lowest GWP retrofit refrigerant for R-134a designed systems. Opteon™ XP10 R-513A A1 631 (573) POE Elastomeric seals replacement or lubricant change not required.

Source: <https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf>

R-513A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HFC R-407A

**Replaces:** R-22

**GWP:** 2107

**Compatible lubricant:** POE-32

> HFC R-407A 2107 R-22 L,M L,M POE-32

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HFC R-407A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HFC R-407C

**Replaces:** R-22

**Trade name(s):** Freon 9000/KLEA 66

**GWP:** 1774

**Compatible lubricant:** POE-32

> HFC R-407C 1774 R-22 L,M,H L,M,H POE-32 Freon 9000/KLEA 66

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HFC R-407C — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HFC R-407F

**Replaces:** R-22

**GWP:** 1825

**Compatible lubricant:** POE-32

**Listing status / notes:** Discus™ and select refrigeration scroll models (ZF/ZB)

> HFC R-407F 1825 R-22 L,M L,M POE-32 Discus™ and select refrigeration scroll models (ZF/ZB)

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HFC R-407F — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HFC R-422A

**Replaces:** R-22

**GWP:** 3143

**Compatible lubricant:** POE-32

**Listing status / notes:** Discus supermarket racks only

> HFC R-422A 3143 R-22 L,M POE-32 MIN AB Discus supermarket racks only

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HFC R-422A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HFC R-422D

**Replaces:** R-22

**GWP:** 2729

**Compatible lubricant:** POE-32

**Listing status / notes:** Discus supermarket racks only

> HFC R-422D 2729 R-22 L,M POE-32 MIN AB Discus supermarket racks only

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HFC R-422D — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HFC R-438A

**Replaces:** R-22

**Trade name(s):** Freon MO99

**GWP:** 2265

**Compatible lubricant:** POE-32

**Listing status / notes:** Discus supermarket racks only

> HFC R-438A 2265 R-22 L,M POE-32 MIN AB Discus supermarket racks only; Freon MO99

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HFC R-438A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HFC-R427A

**Replaces:** R-22

**GWP:** 2138

**Compatible lubricant:** POE-32

**Listing status / notes:** Discus supermarket racks only

> HFC-R427A 2138 R-22 L,M POE-32 Discus supermarket racks only

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HFC-R427A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-407H

**Replaces:** R-22/R-404A

**GWP:** 1495

**Compatible lubricant:** POE-32

**Listing status / notes:** Discus models and Copeland ZB and ZF scrolls for refrigerated rack retrofit

> R-407H 1495 R-22/R-404A L,M POE-32 Discus models and Copeland ZB and ZF scrolls for refrigerated rack retrofit

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

R-407H — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-448A

**Replaces:** R-22/R-404A

**Trade name(s):** Solstice™ N40

**GWP:** 1387

**Compatible lubricant:** POE-32

> R-22/R-404A L,M L,M POE-32 Solstice™ N40 R-448A 1387

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

R-448A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-449A

**Replaces:** R-22/R-404A

**Trade name(s):** Opteon™ XP40

**GWP:** 1396

**Compatible lubricant:** POE-32

> R-22/R-404A L,M L,M POE-32 Opteon™ XP40 R-449A 1396

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

R-449A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-452A

**Replaces:** R-22/R-404A

**Trade name(s):** OPTEON™ XP44

**GWP:** 2140

**Compatible lubricant:** POE-32

**Listing status / notes:** OPTEON™ XP44 for U.S. and European pre-approved applications only

> R-452A 2140 R-22/R-404A L,M L,M POE-32 OPTEON™ XP44 for U.S. and European pre-approved applications only

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

R-452A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-404A

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-404A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-449A

**Replaces:** R-22 , R-407A, R-407F

**Trade name(s):** Opteon™ XP40

**ASHRAE safety class:** A1

**GWP:** 1397 (1282)

**Compatible lubricant:** POE

> R-22 , R-407A, R-407F Opteon™ XP40 R-449A A1 1397 (1282) POE Opteon™ XP40 retrofits will require replacement of critical elastomeric

Source: <https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf>


**Refrigerant:** R-407A

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-407A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-407C

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-407C — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-407C

**Replaces:** R-22

**Trade name(s):** Freon™ 407C

**ASHRAE safety class:** A1

**GWP:** 1774 (1624)

**Compatible lubricant:** POE

> R-22 Replacements for Great choice in systems where changing to POE oil is not practical, Freon™ NU-22B™ R-422B A1 2525 (2289) MO, AB, POE A/C, Heat Pumps elastomeric seals require replacement. Closest performance match to R-22 in A/C applications. Freon™ 407C R-407C A1 1774 (1624) POE Retrofits require a lubricant change to POE oil and replacement

Source: <https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf>


**Refrigerant:** R-407F

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-407F — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-417A

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-417A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-417B

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-417B — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-421A

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-421A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-421B

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-421B — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-422A

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-422A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-422B

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-422B — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-422B

**Replaces:** R-22

**Trade name(s):** Freon™ NU-22B™

**ASHRAE safety class:** A1

**GWP:** 2525 (2289)

**Compatible lubricant:** MO, AB, POE

> R-22 Replacements for Great choice in systems where changing to POE oil is not practical, Freon™ NU-22B™ R-422B A1 2525 (2289) MO, AB, POE A/C, Heat Pumps elastomeric seals require replacement.

Source: <https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf>


**Refrigerant:** R-422C

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-422C — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-422D

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-422D — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-424A

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-424A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-427A

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-427A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-428A

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-428A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-434A

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-434A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-438A

**Replaces:** R-22

**Trade name(s):** Freon™ MO99

> Freon™ MO99 (R-438A) is the best overall all performance when using R-407C? match (energy efficiency, capacity, operating pressures, and If R-407C is used without a full oil change to POE, there is mass flow rates) to R-22 in air conditioning applications.

Source: <https://www.freon.com/en/-/media/files/freon/freon-mo99-faq.pdf>

R-438A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-438A

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>


**Refrigerant:** R-438A

**Replaces:** R-22

**Trade name(s):** Freon™ MO99™

**ASHRAE safety class:** A1

**GWP:** 2264 (2059)

**Compatible lubricant:** MO, AB, POE

> Freon™ MO99™ R-438A A1 2264 (2059) MO, AB, POE elastomeric seals require replacement. R-22 Replacements for Great choice in systems where changing to POE oil is not practical,

Source: <https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf>


**Refrigerant:** R-507A

**Replaces:** R-22

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: <https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf>

R-507A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R427A

**Replaces:** R-22

> Arkema recommends using Forane® 427A (R427A) - The EASY RETROFIT™ for your R-22 retrofit solution.

Source: <https://forane.arkema.com/en/forane-refrigerants/forane-retrofits/the-drop-in-myth/>

R427A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-290 propane

**ASHRAE safety class:** A3

**GWP:** 3

**Compatible lubricant:** POE-32

**Listing status / notes:** For use with specific Copeland compressors manufactured in India for R-290

> R-290 propane A3 3 POE-32 For use with specific Copeland compressors manufactured in India for R-290

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

R-290 propane — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-290 (Propane)

**Retrofit / new:** N

**ASHRAE safety class:** A3

**GWP:** 3

**Listing status / notes:** Acceptable with Use Conditions : For use in self-contained room air conditioning; see rule for detailed conditions.

> R-290 (Propane) | | N | 0 | 3 | A3 | <https://www.govinfo.gov/content/pkg/FR-2015-04-10/pdf/2015-07895.pdf> April 10, 2015 (pdf) (769 KB) | Acceptable with Use Conditions : For use in self-contained room air conditioning; see rule for detailed conditions. |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-290 (Propane) — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-290

**ASHRAE safety class:** A3

> Using these safety groups, HFO-1234ze(E), HFC-32 and the refrigerant blends R-452B, R-454A, R-454B, R-454C, R-457A, and R-516A are in the A2L Safety Group, while R-290, R-441A, and the components of HCR 4141 are in the A3 Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

R-290 — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-454A

**Replaces:** R-404A

**Trade name(s):** Opteon™ XL40

**ASHRAE safety class:** A2L

**GWP:** 239 (238)

> Opteon™ XL40 R-454A R-404A A2L 239 (238) -54 Freon™ 410A R-410A N/A A1 2088 (1924) -61

Source: <https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf>

R-454A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-449A

**Replaces:** R-404A, R-507

**Trade name(s):** Opteon™ XP40

**ASHRAE safety class:** A1

**GWP:** 1397 (1282)

**Compatible lubricant:** POE

> Opteon™ XP40 R-449A A1 1397 (1282) POE TXVs and in most cases it is suggested to replace the R-404A power element to a R-449A power element. Consult compressor manufacturer R-404A, R-507 guidelines for necessity of demand cooling in low temperature

Source: <https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf>

R-449A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-452A

**Replaces:** R-404A, R-507

**Trade name(s):** Opteon™ XP44

**ASHRAE safety class:** A1

**GWP:** 2140 (1945)

**Compatible lubricant:** POE

> R-404A, R-507 guidelines for necessity of demand cooling in low temperature applications. Replacements Discharge temperature and mass flow match to R-404A/R-507. Best Opteon™ XP44 R-452A A1 2140 (1945) POE used in situations where liquid injection cannot be installed on the low

Source: <https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf>

R-452A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-404A

**Trade name(s):** SUVA HP-62

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 3,920

**Listing status / notes:** Acceptable

> R-404A | SUVA HP-62 | R/N | 0 | 3,920 | A1 | <https://www.govinfo.gov/content/pkg/FR-2002-12-20/pdf/02-32130.pdf> December 20, 2002 (pdf) (168 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-404A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-454C

**Replaces:** R-407A

**Trade name(s):** Opteon™ XL20

**ASHRAE safety class:** A2L

**GWP:** 148 (146)

> Opteon™ XL20 R-454C R-407A A2L 148 (146) -50 Opteon™ XL41 R-454B R-410A A2L 466 (467) -51

Source: <https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf>

R-454C — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-407A

**Trade name(s):** Klea 60, Klea 407A

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 2,110

**Listing status / notes:** Acceptable

> R-407A | Klea 60, Klea 407A | R/N | 0 | 2,110 | A1 | <https://www.govinfo.gov/content/pkg/FR-2009-01-02/pdf/E8-31225.pdf> January 2, 2009 (pdf) (173 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-407A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-454C

**Replaces:** R-407C

**Trade name(s):** Opteon™ XL20

**ASHRAE safety class:** A2L

**GWP:** 148 (146)

> Opteon™ XL10 R-1234yf R-134a A2L 4 (1) -21 Opteon™ XL20 R-454C R-407C A2L 148 (146) -50

Source: <https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf>


**Refrigerant:** R-407C

**Trade name(s):** Suva 407C, Klea 407C

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 1,770

**Listing status / notes:** Acceptable

> R-407C | Suva 407C, Klea 407C | R/N | 0 | 1,770 | A1 | <https://www.govinfo.gov/content/pkg/FR-1996-02-08/pdf/96-2723.pdf> February 8, 1996 (pdf) (152 KB); <https://www.govinfo.gov/content/pkg/FR-2002-12-20/pdf/02-32130.pdf> December 20, 2002 (pdf) (168 KB); <https://www.govinfo.gov/content/pkg/FR-2003-08-21/pdf/03-21425.pdf> August 21, 2003 (pdf) (161 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-407C — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-407F

**Trade name(s):** Genetron Performax LT

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 1,820

**Listing status / notes:** Acceptable

> R-407F | Genetron Performax LT | R/N | 0 | 1,820 | A1 | <https://www.govinfo.gov/content/pkg/FR-2011-10-04/pdf/2011-25391.pdf> October 4, 2011 (pdf) (201 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-407F — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-454B

**Replaces:** R-410A

**Compatible lubricant:** POE oil

> R-454B is now a primary replacement for R-410A. Due to • Liquid drain line velocity kept below 100fpm this, compressors are—and will continue to be—available. The • All sizes indicate outside dimensions type K or L copper tubing components in R-454B (R-32 / R-1234yf) are well-known • Equivalent length should include equivalent length for fittings. Refer to fluids and should pose no complications for compressor ASHRAE guidelines. manufacturers. R-454B generally uses POE oil.

Source: <https://prod-edam.honeywell.com/content/dam/honeywell-edam/pmt/oneam/en-us/refrigerants/documents/pmt-am-solstice-454b-applications-guide.pdf>

R-454B — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-454B

**Replaces:** R-410A

**ASHRAE safety class:** A2L

> For Carrier and its associated brands, that means a transition from R-410A to R-454B, which has one fourth the GWP of R-410A*. R-454B is in a specific class of refrigerants known as A2L, whereas R-410A is a class A1 refrigerant.

Source: <https://www.shareddocs.com/hvac/docs/1006/Public/06/570-178.pdf>


**Refrigerant:** R-454B

**Replaces:** R-410A

**Trade name(s):** Opteon™ XL41

**ASHRAE safety class:** A2L

**GWP:** 466 (467)

> Opteon™ XL20 R-454C R-407A A2L 148 (146) -50 Opteon™ XL41 R-454B R-410A A2L 466 (467) -51

Source: <https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf>


**Refrigerant:** R-410A

**Trade name(s):** AZ-20, Suva 9100, Puron

**Retrofit / new:** N

**ASHRAE safety class:** A1

**GWP:** 2,090

**Listing status / notes:** Acceptable

> R-410A | AZ-20, Suva 9100, Puron | N | 0 | 2,090 | A1 | <https://www.govinfo.gov/content/pkg/FR-1996-02-08/pdf/96-2723.pdf> February 8, 1996 (pdf) (152 KB); <https://www.govinfo.gov/content/pkg/FR-2002-12-20/pdf/02-32130.pdf> December 20, 2002 (pdf) (168 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-410A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-410B

**Retrofit / new:** N

**ASHRAE safety class:** A1

**GWP:** 2,230

**Listing status / notes:** Acceptable

> R-410B | | N | 0 | 2,230 | A1 | <https://www.govinfo.gov/content/pkg/FR-1996-02-08/pdf/96-2723.pdf> February 8, 1996 (pdf) (152 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-410B — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-417A

**Trade name(s):** ISCEON 59, NU-22

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 2,350

**Listing status / notes:** Acceptable

> R-417A | ISCEON 59, NU-22 | R/N | 0 | 2,350 | A1 | <https://www.govinfo.gov/content/pkg/FR-1999-12-06/pdf/99-31544.pdf> December 6, 1999 (pdf) (226 KB); <https://www.govinfo.gov/content/pkg/FR-2010-06-16/pdf/2010-14510.pdf> June 16, 2010 (pdf) (229 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-417A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-417C

**Trade name(s):** Hot Shot 2

**Retrofit / new:** R

**ASHRAE safety class:** A1

**GWP:** 1,820

**Listing status / notes:** Acceptable

> R-417C | Hot Shot 2 | R | 0 | 1,820 | A1 | <https://www.govinfo.gov/content/pkg/FR-2011-10-04/pdf/2011-25391.pdf> October 4, 2011 (pdf) (201 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-417C — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-421A

**Trade name(s):** Choice R-421A

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 2,630

**Listing status / notes:** Acceptable

> R-421A | Choice R-421A | R/N | 0 | 2,630 | A1 | <https://www.govinfo.gov/content/pkg/FR-2006-09-28/pdf/E6-15833.pdf> September 28, 2006 (pdf) (183 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-421A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-422B

**Trade name(s):** ICOR XAC1, NU-22B

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 2,530

**Listing status / notes:** Acceptable

> R-422B | ICOR XAC1, NU-22B | R/N | 0 | 2,530 | A1 | <https://www.govinfo.gov/content/pkg/FR-2006-03-29/pdf/06-3030.pdf> March 29, 2006 (pdf) (181 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-422B — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-422C

**Trade name(s):** ICOR XLT1

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 3,390

**Listing status / notes:** Acceptable

> R-422C | ICOR XLT1 | R/N | 0 | 3,390 | A1 | <https://www.govinfo.gov/content/pkg/FR-2006-03-29/pdf/06-3030.pdf> March 29, 2006 (pdf) (181 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-422C — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-422D

**Trade name(s):** ISCEON MO29

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 2,730

**Listing status / notes:** Acceptable

> R-422D | ISCEON MO29 | R/N | 0 | 2,730 | A1 | <https://www.govinfo.gov/content/pkg/FR-2006-09-28/pdf/E6-15833.pdf> September 28, 2006 (pdf) (183 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-422D — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-424A

**Trade name(s):** RS-44

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 2,440

**Listing status / notes:** Acceptable

> R-424A | RS-44 | R/N | 0 | 2,440 | A1 | <https://www.govinfo.gov/content/pkg/FR-2006-09-28/pdf/E6-15833.pdf> September 28, 2006 (pdf) (183 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-424A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-427A

**Trade name(s):** Forane 427A

**Retrofit / new:** R

**ASHRAE safety class:** A1

**GWP:** 2,140

**Listing status / notes:** Acceptable

> R-427A | Forane 427A | R | 0 | 2,140 | A1 | <https://www.govinfo.gov/content/pkg/FR-2009-01-02/pdf/E8-31225.pdf> January 2, 2009 (pdf) (173 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-427A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-434A

**Trade name(s):** RS-45

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 3,250

**Listing status / notes:** Acceptable

> R-434A | RS-45 | R/N | 0 | 3,250 | A1 | <https://www.govinfo.gov/content/pkg/FR-2007-10-04/pdf/E7-19545.pdf> October 4, 2007 (pdf) (163 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-434A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-437A

**Trade name(s):** KDD6, ISCEON MO49 Plus

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 1,810

**Listing status / notes:** Acceptable

> R-437A | KDD6, ISCEON MO49 Plus | R/N | 0 | 1,810 | A1 | <https://www.govinfo.gov/content/pkg/FR-2009-01-02/pdf/E8-31225.pdf> January 2, 2009 (pdf) (173 KB); <https://www.govinfo.gov/content/pkg/FR-2010-06-16/pdf/2010-14510.pdf> June 16, 2010 (pdf) (229 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-437A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-438A

**Trade name(s):** KDD5, ISCEON MO99

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 2,270

**Listing status / notes:** Acceptable

> R-438A | KDD5, ISCEON MO99 | R/N | 0 | 2,270 | A1 | <https://www.govinfo.gov/content/pkg/FR-2007-10-04/pdf/E7-19545.pdf> October 4, 2007 (pdf) (163 KB); <https://www.govinfo.gov/content/pkg/FR-2010-06-16/pdf/2010-14510.pdf> June 16, 2010 (pdf) (229 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-438A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-441A

**ASHRAE safety class:** A3

> Using these safety groups, HFO-1234ze(E), HFC-32 and the refrigerant blends R-452B, R-454A, R-454B, R-454C, R-457A, and R-516A are in the A2L Safety Group, while R-290, R-441A, and the components of HCR 4141 are in the A3 Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

R-441A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-441A

**Retrofit / new:** N

**ASHRAE safety class:** A3

**GWP:** <5

**Listing status / notes:** Acceptable with Use Conditions : For use in self-contained room air conditioning; see rule for detailed conditions.

> R-441A | | N | 0 | <5 | A3 | <https://www.govinfo.gov/content/pkg/FR-2015-04-10/pdf/2015-07895.pdf> April 10, 2015 (pdf) (769 KB) | Acceptable with Use Conditions : For use in self-contained room air conditioning; see rule for detailed conditions. |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>


**Refrigerant:** R-443A

**Retrofit / new:** N

**ASHRAE safety class:** A3

**GWP:** 2.5

**Listing status / notes:** Unacceptable , as of January 3, 2017.

> R-443A | | N | 0 | 2.5 | A3 | <https://www.govinfo.gov/content/pkg/FR-2016-12-01/pdf/2016-25167.pdf> December 1, 2016 (pdf) (969 KB) | Unacceptable , as of January 3, 2017. |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-443A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-444A

**Retrofit / new:** retrofit

**Listing status / notes:** acceptable, subject to use conditions

> List the blend R-444A as acceptable, subject to use conditions, in retrofit LMDV MVACs and retrofit heavy-duty (HD) pickup trucks and van MVACs (complete and incomplete);

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

R-444A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-444A

**ASHRAE safety class:** A2L

> ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>


**Refrigerant:** R-452B

**ASHRAE safety class:** A2L

> Using these safety groups, HFO-1234ze(E), HFC-32 and the refrigerant blends R-452B, R-454A, R-454B, R-454C, R-457A, and R-516A are in the A2L Safety Group, while R-290, R-441A, and the components of HCR 4141 are in the A3 Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

R-452B — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-452B

**Trade name(s):** Opteon™ XL55

**Retrofit / new:** N

**ASHRAE safety class:** A2L

**GWP:** 700

**Listing status / notes:** Acceptable with Use Conditions: See rule for detailed conditions.

> R-452B | Opteon™ XL55 | N | 0 | 700 | A2L | <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>


**Refrigerant:** R-453A

**Retrofit / new:** retrofit

**Listing status / notes:** acceptable, subject to use conditions

> List the blend R-453A as acceptable, subject to use conditions, in retrofit MVACs on buses and trains; and

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

R-453A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-453A

**ASHRAE safety class:** A1

> ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>


**Refrigerant:** R-454A

**ASHRAE safety class:** A2L

> Using these safety groups, HFO-1234ze(E), HFC-32 and the refrigerant blends R-452B, R-454A, R-454B, R-454C, R-457A, and R-516A are in the A2L Safety Group, while R-290, R-441A, and the components of HCR 4141 are in the A3 Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

R-454A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-454A

**Trade name(s):** Opteon™ XL40

**Retrofit / new:** N

**ASHRAE safety class:** A2L

**GWP:** 240

**Listing status / notes:** Acceptable with Use Conditions: See rule for detailed conditions.

> R-454A | Opteon™ XL40 | N | 0 | 240 | A2L | <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>


**Refrigerant:** R-454B

**Trade name(s):** Solstice® 454B

**ASHRAE safety class:** A2L

**GWP:** 467 (AR5)

> Solstice® 454B (R-454B) is a mildly flammable (A2L) stricter A2 usage requirements. refrigerant having a boiling point of -58.1o F (average of dew and bubble) at 0 psig. R-454B will primarily be used for air Within ASHRAE there are many ways in which an A2L conditioning and reversible heating systems, especially in refrigerant such as R-454B can be utilized. A few are residential and light commercial applications. highlighted below (see ASHRAE 15 for full details): The environmental properties of Solstice® 454B (R-454B) • Self-contained commercial occupancy, refrigerant include a zero Ozone Depletion Potential (ODP) and a GWP of charge < 22lb 467 (AR5).

Source: <https://prod-edam.honeywell.com/content/dam/honeywell-edam/pmt/oneam/en-us/refrigerants/documents/pmt-am-solstice-454b-applications-guide.pdf>

R-454B — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-454B

**ASHRAE safety class:** A2L

**Compatible lubricant:** POE oil

**Listing status / notes:** do not permit mixing and matching any components designed for an A1 refrigerant

> than R-454B will need to be upgraded. As of this document, current building codes and EPA regulations do not permit mixing and matching any components designed for an A1 refrigerant, such as R-410A with any components designed for an A2L refrigerant such as R-454B. This includes air handling unit components. Should the installer replace any A1 system with one containing A2Ls, the installer must also confirm that all connected refrigerant piping and and refrigerant specialties are also certified and listed for use with the specific A2L refrigerant. Failure to do so will create a hazardous and unsafe condition. Every part of an existing split system needs to be analyzed to determine if it can be reused in an R-454B and POE oil system:

Source: <https://www.trane.com/content/dam/Trane/Commercial/global/products-systems/equipment/unitary/split-systems/rauj-cauj-20-to-120-tons/SS-APG018A-EN_11102024.pdf>


**Refrigerant:** R-454B

**ASHRAE safety class:** A2L

> Using these safety groups, HFO-1234ze(E), HFC-32 and the refrigerant blends R-452B, R-454A, R-454B, R-454C, R-457A, and R-516A are in the A2L Safety Group, while R-290, R-441A, and the components of HCR 4141 are in the A3 Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>


**Refrigerant:** R-454B

**Trade name(s):** Opteon™ XL41

**Retrofit / new:** N

**ASHRAE safety class:** A2L

**GWP:** 470

**Listing status / notes:** Acceptable with Use Conditions: See rule for detailed conditions.

> R-454B | Opteon™ XL41 | N | 0 | 470 | A2L | <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>


**Refrigerant:** R-454C

**ASHRAE safety class:** A2L

> Using these safety groups, HFO-1234ze(E), HFC-32 and the refrigerant blends R-452B, R-454A, R-454B, R-454C, R-457A, and R-516A are in the A2L Safety Group, while R-290, R-441A, and the components of HCR 4141 are in the A3 Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

R-454C — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-454C

**Trade name(s):** Opteon™ XL20

**Retrofit / new:** N

**ASHRAE safety class:** A2L

**GWP:** 150

**Listing status / notes:** Acceptable with Use Conditions: See rule for detailed conditions.

> R-454C | Opteon™ XL20 | N | 0 | 150 | A2L | <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>


**Refrigerant:** R-456A

**Retrofit / new:** retrofit

**Listing status / notes:** acceptable, subject to use conditions

> List the blend R-456A as acceptable, subject to use conditions, in retrofit LMDV MVACs, retrofit HD pickup trucks and van MVACs (complete and incomplete), retrofit HDOH MVACs, and retrofit MVACs on buses and trains;

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

R-456A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-456A

**ASHRAE safety class:** A1

> ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>


**Refrigerant:** R-457A

**ASHRAE safety class:** A2L

> Using these safety groups, HFO-1234ze(E), HFC-32 and the refrigerant blends R-452B, R-454A, R-454B, R-454C, R-457A, and R-516A are in the A2L Safety Group, while R-290, R-441A, and the components of HCR 4141 are in the A3 Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

R-457A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-457A

**Trade name(s):** Forane® 457A

**Retrofit / new:** N

**ASHRAE safety class:** A2L

**GWP:** 140

**Listing status / notes:** Acceptable with Use Conditions: See rule for detailed conditions.

> R-457A | Forane® 457A | N | 0 | 140 | A2L | <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>


**Refrigerant:** R-458A

**Trade name(s):** Bluon TdX 20

**Retrofit / new:** R

**ASHRAE safety class:** A1

**GWP:** 1,650

**Listing status / notes:** Acceptable

> R-458A | Bluon TdX 20 | R | 0 | 1,650 | A1 | <https://www.govinfo.gov/content/pkg/FR-2017-07-21/pdf/2017-15379.pdf> July 21, 2017 (pdf) (314 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-458A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-480A

**Retrofit / new:** retrofit

**Listing status / notes:** acceptable, subject to use conditions

> List the blend R-480A as acceptable, subject to use conditions, in retrofit LMDV MVACs, retrofit MVACs on HD pickup trucks and vans (complete and incomplete), retrofit HDOH MVACs, and retrofit MVACs on buses and trains;

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

R-480A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-480A

**ASHRAE safety class:** A1

> ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>


**Refrigerant:** HCFC R-402A

**Replaces:** R-502

**Trade name(s):** Freon HP80

**GWP:** 2788

**Compatible lubricant:** AB & MIN

**Listing status / notes:** For service applications only

> HCFC R-402A 2788 R-502 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: Freon HP80

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HCFC R-402A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HCFC R-402B

**Replaces:** R-502

**Trade name(s):** Freon HP81

**GWP:** 2416

**Compatible lubricant:** AB & MIN

**Listing status / notes:** For service applications only

> HCFC R-402B 2416 R-502 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: Freon HP81

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HCFC R-402B — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HCFC R-408A

**Replaces:** R-502

**Trade name(s):** FX10

**GWP:** 3152

**Compatible lubricant:** AB & MIN

**Listing status / notes:** For service applications only

> HCFC R-408A 3152 R-502 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: FX10

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HCFC R-408A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HFC R-404A

**Replaces:** R-502

**Trade name(s):** Freon HP62, Forane™ FX70

**GWP:** 3922

**Compatible lubricant:** POE-32

> R-502 L,M L,M POE-32 Freon HP62, Forane™ FX70 HFC R-404A 3922 R-502 L,M L,M POE-22C For use with compressors manufactured in India

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HFC R-404A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** HFC R-507

**Replaces:** R-502

**Trade name(s):** Genetron™ AZ50

**GWP:** 3985

**Compatible lubricant:** POE-32

> HFC R-507 3985 R-502 L,M L,M POE-32 Genetron™ AZ50

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

HFC R-507 — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-507, R-507A

**Trade name(s):** AZ-50

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 3,990

**Listing status / notes:** Acceptable

> R-507, R-507A | AZ-50 | R/N | 0 | 3,990 | A1 | <https://www.govinfo.gov/app/details/FR-1996-09-05/96-22649> September 5, 1996 ; <https://www.govinfo.gov/content/pkg/FR-2002-12-20/pdf/02-32130.pdf> December 20, 2002 (pdf) (168 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-507, R-507A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-513A

**Trade name(s):** Opteon® XP-10

**Retrofit / new:** N

**ASHRAE safety class:** A1

**GWP:** 630

**Listing status / notes:** Acceptable in self-contained units.

> R-513A | Opteon® XP-10 | N | 0 | 630 | A1 | <https://www.govinfo.gov/content/pkg/FR-2024-12-11/pdf/2024-28307.pdf> December 11, 2024 (pdf) (300 KB) | Acceptable in self-contained units. |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

R-513A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-516A

**ASHRAE safety class:** A2L

**Listing status / notes:** acceptable, subject to use conditions

> The EPA is proposing to list HCR 4141, HFO-1234ze(E), and R-516A as acceptable, subject to use conditions, for this end-use. HCR 4141 is a higher flammability refrigerant blend with each component in the A3 Safety Group. HFO-1234ze(E) and R-516A are lower flammability refrigerants, both in the A2L Safety Group.

Source: <https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives>

R-516A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-704 helium

**GWP:** 1

**Compatible lubricant:** PAG

**Listing status / notes:** Copeland ZC scroll models only

> R-704 helium 1 Cryogenic PAG Copeland ZC scroll models only

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

R-704 helium — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-744 CO2

**GWP:** 1

**Compatible lubricant:** PAG-68

> R-744 CO2 1 PAG-68 POE-68 RFL68EP for CO2 compressor manufactured in Europe

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

R-744 CO2 — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-513A

**Replaces:** R12

**GWP:** 630

**Compatible lubricant:** POE-22D

**Listing status / notes:** Compressors produced in Brazil

> R-513A 630 R12 L,M L,M POE-22D Compressors produced in Brazil

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>


**Refrigerant:** R-454A

**Replaces:** R22/R404A

**ASHRAE safety class:** A2L

**GWP:** 239

> R-454A 239 R22/R404A – L,M A2L

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

R-454A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-454C

**Replaces:** R22/R404A

**GWP:** 148

> R-454C 148 R22/R404A – L,M

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>


**Refrigerant:** R-32

**Replaces:** R410A

**GWP:** 675

**Compatible lubricant:** POE-46

> R410A M,H M,H POE-46 SP32 SP32covers VE/ZE compressors manufactured in Asia only R-32 675

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

R-32 — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-454B

**Replaces:** R410A

**GWP:** 466

**Compatible lubricant:** POE-32

**Listing status / notes:** Not for retrofit into A1 systems

> R-454B 466 R410A – M,H POE-32 Not for retrofit into A1 systems

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

R-454B — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** R-455A

**Replaces:** R410A

**GWP:** 145

> R-455A 145 R410A – M,H

Source: <https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11>

R-455A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** RS-44 (2003 formulation)

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** 2,420

**Listing status / notes:** Acceptable

> RS-44 (2003 formulation) | | R/N | 0 | 2,420 | A1 | <https://www.govinfo.gov/content/pkg/FR-2010-06-16/pdf/2010-14510.pdf> June 16, 2010 (pdf) (229 KB) | Acceptable |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

RS-44 (2003 formulation) — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant


**Refrigerant:** THR-03

**Retrofit / new:** R/N

**ASHRAE safety class:** A1

**GWP:** N/A

**Listing status / notes:** Acceptable with Use Conditions : For use in residential window unit air conditioning.

> THR-03 | | R/N | 0 | N/A | A1 | <https://www.govinfo.gov/content/pkg/FR-1999-12-06/pdf/99-31544.pdf> December 6, 1999 (pdf) (226 KB) | Acceptable with Use Conditions : For use in residential window unit air conditioning. |

Source: <https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps>

THR-03 — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant