# R-454C — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant

For R-454C, trade name(s) is Opteon™ XL20; retrofit / new is N; ashrae safety class is A2L; gwp is 150; listing status / notes is Acceptable with Use Conditions: See rule for detailed conditions, verified against its source on 2026-08-11.

- **Refrigerant:** R-454C _(verified: appears in the quote below)_
- **Trade name(s):** Opteon™ XL20 _(verified: appears in the quote below)_
- **Retrofit / new:** N _(verified: appears in the quote below)_
- **ASHRAE safety class:** A2L _(verified: appears in the quote below)_
- **GWP:** 150 _(verified: appears in the quote below)_
- **Listing status / notes:** Acceptable with Use Conditions: See rule for detailed conditions. _(verified: appears in the quote below)_

## What the source says

> R-454C | Opteon™ XL20 | N | 0 | 150 | A2L | <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. |

## What federalregister.gov says

> Using these safety groups, HFO-1234ze(E), HFC-32 and the refrigerant blends R-452B, R-454A, R-454B, R-454C, R-457A, and R-516A are in the A2L Safety Group, while R-290, R-441A, and the components of HCR 4141 are in the A3 Safety Group.

Source: https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives

## Source

- https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps
- https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives

Last verified: 2026-08-11. Review by: 2027-08-11.
Part of [HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant](https://referencesource.org/hvac-component-refrigerant-compatibility/).