# R-452A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant

For R-452A, replaces is R-404A, R-507; trade name(s) is Opteon™ XP44; ashrae safety class is A1; gwp is 2140 (1945); compatible lubricant is POE, verified against its source on 2026-08-11.

- **Refrigerant:** R-452A _(verified: appears in the quote below)_
- **Replaces:** R-404A, R-507 _(verified: appears in the quote below)_
- **Trade name(s):** Opteon™ XP44 _(verified: appears in the quote below)_
- **ASHRAE safety class:** A1 _(verified: appears in the quote below)_
- **GWP:** 2140 (1945) _(verified: appears in the quote below)_
- **Compatible lubricant:** POE _(verified: appears in the quote below)_

## What the source says

> R-404A, R-507 guidelines for necessity of demand cooling in low temperature applications. Replacements Discharge temperature and mass flow match to R-404A/R-507. Best Opteon™ XP44 R-452A A1 2140 (1945) POE used in situations where liquid injection cannot be installed on the low

## Source

- https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf

Last verified: 2026-08-11. Review by: 2027-08-11.
Part of [HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant](https://referencesource.org/hvac-component-refrigerant-compatibility/).