# R-449A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant

For R-449A, replaces is R-404A, R-507; trade name(s) is Opteon™ XP40; ashrae safety class is A1; gwp is 1397 (1282); compatible lubricant is POE, verified against its source on 2026-08-11.

- **Refrigerant:** R-449A _(verified: appears in the quote below)_
- **Replaces:** R-404A, R-507 _(verified: appears in the quote below)_
- **Trade name(s):** Opteon™ XP40 _(verified: appears in the quote below)_
- **ASHRAE safety class:** A1 _(verified: appears in the quote below)_
- **GWP:** 1397 (1282) _(verified: appears in the quote below)_
- **Compatible lubricant:** POE _(verified: appears in the quote below)_

## What the source says

> Opteon™ XP40 R-449A A1 1397 (1282) POE TXVs and in most cases it is suggested to replace the R-404A power element to a R-449A power element. Consult compressor manufacturer R-404A, R-507 guidelines for necessity of demand cooling in low temperature

## Source

- https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf

Last verified: 2026-08-11. Review by: 2027-08-11.
Part of [HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant](https://referencesource.org/hvac-component-refrigerant-compatibility/).