# R-290 — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant

For R-290, ashrae safety class is A3, verified against its source on 2026-08-11.

- **Refrigerant:** R-290 _(verified: appears in the quote below)_
- **ASHRAE safety class:** A3 _(verified: appears in the quote below)_

## What the source says

> Using these safety groups, HFO-1234ze(E), HFC-32 and the refrigerant blends R-452B, R-454A, R-454B, R-454C, R-457A, and R-516A are in the A2L Safety Group, while R-290, R-441A, and the components of HCR 4141 are in the A3 Safety Group.

## Source

- https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives

Last verified: 2026-08-11. Review by: 2027-08-11.
Part of [HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant](https://referencesource.org/hvac-component-refrigerant-compatibility/).