# R-422B — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant

For R-422B, replaces is R-22; trade name(s) is Freon™ NU-22B™; ashrae safety class is A1; gwp is 2525 (2289); compatible lubricant is MO, AB, POE, verified against its source on 2026-08-11.

- **Refrigerant:** R-422B _(verified: appears in the quote below)_
- **Replaces:** R-22 _(verified: appears in the quote below)_
- **Trade name(s):** Freon™ NU-22B™ _(verified: appears in the quote below)_
- **ASHRAE safety class:** A1 _(verified: appears in the quote below)_
- **GWP:** 2525 (2289) _(verified: appears in the quote below)_
- **Compatible lubricant:** MO, AB, POE _(verified: appears in the quote below)_

## What the source says

> R-22 Replacements for Great choice in systems where changing to POE oil is not practical, Freon™ NU-22B™ R-422B A1 2525 (2289) MO, AB, POE A/C, Heat Pumps elastomeric seals require replacement.

## What epa.gov says

> R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A

Source: https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf

## Source

- https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf
- https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf

Last verified: 2026-08-11. Review by: 2027-08-11.
Part of [HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant](https://referencesource.org/hvac-component-refrigerant-compatibility/).