# R-452A — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant

For R-452A, replaces is R-22/R-404A; trade name(s) is OPTEON™ XP44; gwp is 2140; compatible lubricant is POE-32; listing status / notes is OPTEON™ XP44 for U.S. and European pre-approved applications only, verified against its source on 2026-08-11.

- **Refrigerant:** R-452A _(verified: appears in the quote below)_
- **Replaces:** R-22/R-404A _(verified: appears in the quote below)_
- **Trade name(s):** OPTEON™ XP44 _(verified: appears in the quote below)_
- **GWP:** 2140 _(verified: appears in the quote below)_
- **Compatible lubricant:** POE-32 _(verified: appears in the quote below)_
- **Listing status / notes:** OPTEON™ XP44 for U.S. and European pre-approved applications only _(verified: appears in the quote below)_

## What the source says

> R-452A 2140 R-22/R-404A L,M L,M POE-32 OPTEON™ XP44 for U.S. and European pre-approved applications only

## Source

- https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11

Last verified: 2026-08-11. Review by: 2027-08-11.
Part of [HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant](https://referencesource.org/hvac-component-refrigerant-compatibility/).