# HCR 4141 — HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant

For HCR 4141, listing status / notes is acceptable, subject to use conditions, verified against its source on 2026-08-11.

- **Refrigerant:** HCR 4141 _(verified: appears in the quote below)_
- **Listing status / notes:** acceptable, subject to use conditions _(verified: appears in the quote below)_

## What the source says

> The EPA is proposing to list HCR 4141, HFO-1234ze(E), and R-516A as acceptable, subject to use conditions, for this end-use. HCR 4141 is a higher flammability refrigerant blend with each component in the A3 Safety Group. HFO-1234ze(E) and R-516A are lower flammability refrigerants, both in the A2L Safety Group.

## Source

- https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives

Last verified: 2026-08-11. Review by: 2027-08-11.
Part of [HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant](https://referencesource.org/hvac-component-refrigerant-compatibility/).