# Safrole-free extract of sassafras — Food additive regulatory approval status — US FDA vs EU

For Safrole-free extract of sassafras, jurisdiction is US FDA (21 CFR 172–178); status is permitted; citation is 21 CFR 172.580; use conditions is in accordance with the following prescribed conditions:   ( a ) The additive is the aqueous extract obtained from the root bark of the plant Sassafras albidum (Nuttall) Nees (Fam, recorded from its source on 2026-08-15.

- **Additive:** Safrole-free extract of sassafras _(verified: appears in the quote below)_
- **Jurisdiction:** US FDA (21 CFR 172–178) _(our reading, not quoted from the source)_
- **Status:** permitted _(our reading, not quoted from the source)_
- **Citation:** 21 CFR 172.580 _(our reading, not quoted from the source)_
- **Use conditions:** in accordance with the following prescribed conditions:   ( a ) The additive is the aqueous extract obtained from the root bark of the plant Sassafras albidum (Nuttall) Nees (Fam. _(verified: appears in the quote below)_

## What the source says

> § 172.580 Safrole-free extract of sassafras. The food additive safrole-free extract of sassafras may be safely used in accordance with the following prescribed conditions: ( a ) The additive is the aqueous extract obtained from the root bark of the plant Sassafras albidum (Nuttall) Nees (Fam. Lauraceae).

## Source

- https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172

Last verified: 2026-08-15. Review by: 2027-08-15.
Part of [Food additive regulatory approval status — US FDA vs EU](https://referencesource.org/food-additive-approval-status-us-vs-eu/).