# Dimethyl dicarbonate — Food additive regulatory approval status — US FDA vs EU

For Dimethyl dicarbonate, jurisdiction is US FDA (21 CFR 172–178); status is permitted; citation is 21 CFR 172.133; use conditions is microbial control agent in wine (not to exceed 200 ppm), ready-to-drink teas (not to exceed 250 ppm), carbonated dilute beverages containing juice (not to exceed 250 ppm), and electrolyte beverages (not to exceed 250 ppm); cas no. is 4525-33-1, recorded from its source on 2026-08-15.

- **Additive:** Dimethyl dicarbonate _(verified: appears in the quote below)_
- **Jurisdiction:** US FDA (21 CFR 172–178) _(our reading, not quoted from the source)_
- **Status:** permitted _(our reading, not quoted from the source)_
- **Citation:** 21 CFR 172.133 _(our reading, not quoted from the source)_
- **Use conditions:** microbial control agent in wine (not to exceed 200 ppm), ready-to-drink teas (not to exceed 250 ppm), carbonated dilute beverages containing juice (not to exceed 250 ppm), and electrolyte beverages (not to exceed 250 ppm)
- **CAS No.:** 4525-33-1 _(verified: appears in the quote below)_

## What the source says

> § 172.133 Dimethyl dicarbonate. Dimethyl dicarbonate (CAS Reg. No. 4525-33-1) may be safely used in food in accordance with the following prescribed conditions:

## Source

- https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172/subpart-B

Last verified: 2026-08-15. Review by: 2027-08-15.
Part of [Food additive regulatory approval status — US FDA vs EU](https://referencesource.org/food-additive-approval-status-us-vs-eu/).