**Additive:** Succistearin (stearoyl propylene glycol hydrogen succinate)

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.765

**Use conditions:** in food in accordance with the following prescribed conditions:

 ( a ) The additive is the reaction product of succinic anhydride, fully hydrogenated vegetable oil (predominantly C 16 or C 18 fatty acid chain length), and propylene glycol.

> § 172.765 Succistearin (stearoyl propylene glycol hydrogen succinate). The food additive succistearin (stearoyl propylene glycol hydrogen succinate) may be safely used in food in accordance with the following prescribed conditions: ( a ) The additive is the reaction product of succinic anhydride, fully hydrogenated vegetable oil (predominantly C 16 or C 18 fatty acid chain length), and propylene glycol. ( b ) The additive meets the following specifications:

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Succistearin (stearoyl propylene glycol hydrogen succinate) — Food additive regulatory approval status — US FDA vs EU


**Additive:** Sucralose

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.831

**CAS No.:** 56038-13-2

> ( 2 ) As a dough conditioner in bread baking, when such use is permitted by an appropriate food standard, at a level not to exceed 0.5 percent by weight of the flour used. § 172.831 Sucralose. ( a ) Sucralose is the chemical 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside (CAS Reg. No. 56038-13-2).

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Sucralose — Food additive regulatory approval status — US FDA vs EU


**Additive:** Sucrose acetate isobutyrate (SAIB)

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.833

**Use conditions:** in foods in accordance with the following prescribed conditions:

 ( a ) Sucrose acetate isobutyrate (CAS Reg.

**CAS No.:** 27216-37-1

> § 172.833 Sucrose acetate isobutyrate (SAIB). Sucrose acetate isobutyrate may be safely used in foods in accordance with the following prescribed conditions: ( a ) Sucrose acetate isobutyrate (CAS Reg. No. 27216-37-1), or SAIB, is the chemical alpha -D-glucopyranoside, O-acetyl-tris-O-(2-methyl-1-oxopropyl)- beta -D-fructofuranosyl, acetate tris(2-methyl propanoate).

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Sucrose acetate isobutyrate (SAIB) — Food additive regulatory approval status — US FDA vs EU


**Additive:** Sucrose fatty acid esters

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.859

**Use conditions:** in accordance with the following prescribed conditions:

 ( a ) Sucrose fatty acid esters are the mono-, di-, and tri-esters of sucrose with fatty acids and are derived from sucrose and edible tallow or hydrogenated edible tallow or edible vegetable oils.

> Sucrose fatty acid esters identified in this section may be safely used in accordance with the following prescribed conditions: ( a ) Sucrose fatty acid esters are the mono-, di-, and tri-esters of sucrose with fatty acids and are derived from sucrose and edible tallow or hydrogenated edible tallow or edible vegetable oils.

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Sucrose fatty acid esters — Food additive regulatory approval status — US FDA vs EU


**Additive:** Sucrose oligoesters

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.869

**Use conditions:** in accordance with the following conditions:

 ( a ) Sucrose oligoesters consist of mixtures of sucrose fatty acid esters with an average degree of esterification ranging from four to seven.

> § 172.869 Sucrose oligoesters. Sucrose oligoesters, as identified in this section, may be safely used in accordance with the following conditions: ( a ) Sucrose oligoesters consist of mixtures of sucrose fatty acid esters with an average degree of esterification ranging from four to seven.

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Sucrose oligoesters — Food additive regulatory approval status — US FDA vs EU


**Additive:** Sugar beet extract flavor base

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.585

**Use conditions:** in food in accordance with the provisions of this section.

> § 172.585 Sugar beet extract flavor base. Sugar beet extract flavor base may be safely used in food in accordance with the provisions of this section.

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Sugar beet extract flavor base — Food additive regulatory approval status — US FDA vs EU


**Additive:** Sulfated butyl oleate

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.270

**Use conditions:** in food, subject to the following prescribed conditions:

 ( a ) The additive is prepared by sulfation, using concentrated sulfuric acid, of a mixture of butyl esters produced by transesterification of an edible vegetable oil using 1-butanol.

> § 172.270 Sulfated butyl oleate. Sulfate butyl oleate may be safely used in food, subject to the following prescribed conditions: ( a ) The additive is prepared by sulfation, using concentrated sulfuric acid, of a mixture of butyl esters produced by transesterification of an edible vegetable oil using 1-butanol.

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Sulfated butyl oleate — Food additive regulatory approval status — US FDA vs EU


**Additive:** Synthetic fatty alcohols

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.864

**Use conditions:** in food and in the synthesis of food components in accordance with the following prescribed conditions:

 ( a ) The food additive consists of any one of the following fatty alcohols:

 ( 1 ) Hexyl, octyl, decyl, lauryl, myristyl, cetyl, and stearyl; manufactured by fractional distillation of alco...

> § 172.864 Synthetic fatty alcohols. Synthetic fatty alcohols may be safely used in food and in the synthesis of food components in accordance with the following prescribed conditions: ( a ) The food additive consists of any one of the following fatty alcohols:

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Synthetic fatty alcohols — Food additive regulatory approval status — US FDA vs EU

jurisdiction, regulatory_citation, status, use_conditions


**Additive:** Synthetic glycerin produced by the hydrogenolysis of carbohydrates

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.866

**Use conditions:** in food, subject to the provisions of this section:

 ( a ) It shall contain not in excess of 0.

> § 172.866 Synthetic glycerin produced by the hydrogenolysis of carbohydrates. Synthetic glycerin produced by the hydrogenolysis of carbohydrates may be safely used in food, subject to the provisions of this section: ( a ) It shall contain not in excess of 0.2 percent by weight of a mixture of butanetriols.

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Synthetic glycerin produced by the hydrogenolysis of carbohydrates — Food additive regulatory approval status — US FDA vs EU


**Additive:** Synthetic isoparaffinic petroleum hydrocarbons

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.882

**Use conditions:** in food, in accordance with the following conditions:

 ( a ) They are produced by synthesis from petroleum gases and consist of a mixture of liquid hydrocarbons meeting the following specifications:

 Boiling point 93-260 °C as determined by ASTM method D86-82, “Standard Method for Distillation ...

> § 172.882 Synthetic isoparaffinic petroleum hydrocarbons. Synthetic isoparaffinic petroleum hydrocarbons may be safely used in food, in accordance with the following conditions: ( a ) They are produced by synthesis from petroleum gases and consist of a mixture of liquid hydrocarbons meeting the following specifications:

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Synthetic isoparaffinic petroleum hydrocarbons — Food additive regulatory approval status — US FDA vs EU


**Additive:** Synthetic paraffin and succinic derivatives

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.275

**Use conditions:** as a component of food, subject to the following restrictions:

 ( a ) The additive is prepared with 50 percent Fischer-Tropsch process synthetic paraffin, meeting the definition and specifications of <https://www.

> § 172.275 Synthetic paraffin and succinic derivatives. Synthetic paraffin and succinic derivatives identified in this section may be safely used as a component of food, subject to the following restrictions: ( a ) The additive is prepared with 50 percent Fischer-Tropsch process synthetic paraffin, meeting the definition and specifications of <https://www.ecfr.gov/current/title-21/section-172.615>

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Synthetic paraffin and succinic derivatives — Food additive regulatory approval status — US FDA vs EU


**Additive:** Synthetic petroleum wax

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.888

**Use conditions:** in or on foods in accordance with the following conditions:

 ( a ) Synthetic petroleum wax is a mixture of solid hydrocarbons, paraffinic in nature, prepared by either catalytic polymerization of ethylene or copolymerization of ethylene with linear (C 3 to C 12 ) alpha-olefins, and refined to me...

> ( c ) Synthetic petroleum wax has a number average molecular weight of not less than 500 nor greater than 1,200 as determined by vapor pressure osmometry. ( d ) Synthetic petroleum wax may contain any antioxidant permitted

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Synthetic petroleum wax — Food additive regulatory approval status — US FDA vs EU


**Additive:** TBHQ (tertiary butylhydroquinone)

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.185

**Use conditions:** antioxidant alone or in combination with BHA and/or BHT; total antioxidant content will not exceed 0.02 percent of the oil or fat content of the food

**CAS No.:** 1948-33-0

> The food additive TBHQ, which is the chemical 2-(1,1-dimethylethyl)-1,4-benzenediol (Chemical Abstracts Service Registry Number 1948-33-0), also known as tertiary butylhydroquinone, may be safely used in food in accordance with the following prescribed conditions

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172/subpart-B>

TBHQ (tertiary butylhydroquinone) — Food additive regulatory approval status — US FDA vs EU

additive_name, jurisdiction, regulatory_citation, status, use_conditions


**Additive:** Terpene resin

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.280

**Use conditions:** in accordance with the following prescribed conditions:

 ( a ) The food additive is the betapinene polymer obtained by polymerizing terpene hydrocarbons derived from wood.

> § 172.280 Terpene resin. The food additive terpene resin may be safely used in accordance with the following prescribed conditions: ( a ) The food additive is the betapinene polymer obtained by polymerizing terpene hydrocarbons derived from wood.

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Terpene resin — Food additive regulatory approval status — US FDA vs EU


**Additive:** THBP (2,4,5-trihydroxybutyrophenone)

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.190

**Use conditions:** antioxidant alone or in combination with other permitted antioxidants; total antioxidant content will not exceed 0.02 percent of the oil or fat content of the food

> The food additive THBP (2,4,5-trihydroxybutyrophenone) may be safely used in food in accordance with the following prescribed conditions: ( a ) The food additive has a melting point of 149 °C-153 °C. ( b ) It is used as an antioxidant alone or in combination with other permitted antioxidants.

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172/subpart-B>

THBP (2,4,5-trihydroxybutyrophenone) — Food additive regulatory approval status — US FDA vs EU


**Additive:** Vitamin D 2

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.379

> § 172.379 Vitamin D 2 . Vitamin D 2 may be used safely in foods as a nutrient supplement defined under <https://www.ecfr.gov/current/title-21/section-170.3#p-170.3(o)(20)> § 170.3(o)(20) of this chapter in accordance with the following prescribed conditions:

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Vitamin D 2  — Food additive regulatory approval status — US FDA vs EU


**Additive:** Vitamin D 3

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.380

> § 172.380 Vitamin D 3 . Vitamin D 3 may be used safely in foods as a nutrient supplement defined under <https://www.ecfr.gov/current/title-21/section-170.3#p-170.3(o)(20)> § 170.3(o)(20) of this chapter in accordance with the following prescribed conditions:

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Vitamin D 3  — Food additive regulatory approval status — US FDA vs EU


**Additive:** Vitamin D2 bakers yeast

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.381

**Use conditions:** source of vitamin D2 and as a leavening agent

> Vitamin D 2 bakers yeast may be used safely in foods as a source of vitamin D 2 and as a leavening agent in accordance with the following prescribed conditions

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Vitamin D2 bakers yeast — Food additive regulatory approval status — US FDA vs EU


**Additive:** Vitamin D2 mushroom powder

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.382

**Use conditions:** source of vitamin D2

> Vitamin D 2 mushroom powder may be used safely in foods as a source of vitamin D 2 in accordance with the following prescribed conditions

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Vitamin D2 mushroom powder — Food additive regulatory approval status — US FDA vs EU


**Additive:** Whole fish protein concentrate

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.385

**Use conditions:** food supplement; derived from whole, wholesome hake and hakelike fish, herring, menhaden, and anchovy

> The food additive whole fish protein concentrate may be safely used as a food supplement in accordance with the following prescribed conditions

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Whole fish protein concentrate — Food additive regulatory approval status — US FDA vs EU


**Additive:** Xanthan gum

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.695

**Use conditions:** in food in accordance with the following prescribed conditions:

 ( a ) The additive is a polysaccharide gum derived from Xanthomonas campestris by a pure-culture fermentation process and purified by recovery with isopropyl alcohol.

> 24, 2023] § 172.695 Xanthan gum. The food additive xanthan gum may be safely used in food in accordance with the following prescribed conditions: ( a ) The additive is a polysaccharide gum derived from Xanthomonas campestris by a pure-culture fermentation process and purified by recovery with isopropyl alcohol.

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Xanthan gum — Food additive regulatory approval status — US FDA vs EU


**Additive:** Xylitol

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.395

**Use conditions:** in foods for special dietary uses, provided the amount used is not greater than that required to produce its intended effect.

> § 172.395 Xylitol. Xylitol may be safely used in foods for special dietary uses, provided the amount used is not greater than that required to produce its intended effect.

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Xylitol — Food additive regulatory approval status — US FDA vs EU


**Additive:** Yeast-malt sprout extract

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.590

**Use conditions:** in food in accordance with the following prescribed conditions:

 ( a ) The additive is produced by partial hydrolysis of yeast extract (derived from Saccharomyces cereviseae, Saccharomyces fragilis, or Candida utilis ) using the sprout portion of malt barley as the source of enzymes.

> § 172.590 Yeast-malt sprout extract. Yeast-malt sprout extract, as described in this section, may be safely used in food in accordance with the following prescribed conditions: ( a ) The additive is produced by partial hydrolysis of yeast extract (derived from Saccharomyces cereviseae, Saccharomyces fragilis, or Candida utilis ) using the sprout portion of malt barley as the source of enzymes. The additive contains a maximum of 6 percent 5′ nucleotides by weight.

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Yeast-malt sprout extract — Food additive regulatory approval status — US FDA vs EU


**Additive:** Yellow prussiate of soda

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.490

**Use conditions:** anticaking agent in salt and adjuvant in production of dendritic crystals of salt

> The food additive yellow prussiate of soda (sodium ferrocyanide decahydrate; Na 4 Fe(CN) 6

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Yellow prussiate of soda — Food additive regulatory approval status — US FDA vs EU


**Additive:** Zinc methionine sulfate

**Jurisdiction:** US FDA (21 CFR 172–178)

**Status:** permitted

**Citation:** 21 CFR 172.399

**Use conditions:** in accordance with the following prescribed conditions:

 ( a ) The additive is the product of the reaction between equimolar amounts of zinc sulfate and DL-methionine in purified water.

**CAS No.:** 56329-42-1

> § 172.399 Zinc methionine sulfate. Zinc methionine sulfate, CAS Reg. No. 56329-42-1, may be safely used in accordance with the following prescribed conditions: ( a ) The additive is the product of the reaction between equimolar amounts of zinc sulfate and DL-methionine in purified water.

Source: <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172>

Zinc methionine sulfate — Food additive regulatory approval status — US FDA vs EU