# Methyl (E)-2-((2S,3S,7aS,12aR,12bS)-3-ethyl-9-fluoro-7a-hydroxy-8- methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate (commonly known as MGM-16; also known as 9-fluoro-dihydro-7-hydroxymitragynine; or 10-fluoro-dihydro-7-hydroxymitragynine (depending on numbering convention)) including its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible. Since nomenclature of this substance is not internationally standardized, compounds of this structure, regardless of numerical designation of atomic positions are covered — Federal controlled substance schedule (I-V) by drug, with DEA code number

For Methyl (E)-2-((2S,3S,7aS,12aR,12bS)-3-ethyl-9-fluoro-7a-hydroxy-8- methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate (commonly known as MGM-16; also known as 9-fluoro-dihydro-7-hydroxymitragynine; or 10-fluoro-dihydro-7-hydroxymitragynine (depending on numbering convention)) including its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible. Since nomenclature of this substance is not internationally standardized, compounds of this structure, regardless of numerical designation of atomic positions are covered, schedule is Schedule I; listed under is Temporary listing of substances subject to emergency scheduling; dea code number is 9674; temporary listing expires is Aug. 26, 2028; cfr citation is 21 CFR 1308.11(h)(91), recorded from its source on 2026-09-01.

- **Substance:** Methyl (E)-2-((2S,3S,7aS,12aR,12bS)-3-ethyl-9-fluoro-7a-hydroxy-8- methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate (commonly known as MGM-16; also known as 9-fluoro-dihydro-7-hydroxymitragynine; or 10-fluoro-dihydro-7-hydroxymitragynine (depending on numbering convention)) including its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible. Since nomenclature of this substance is not internationally standardized, compounds of this structure, regardless of numerical designation of atomic positions are covered _(verified: appears in the quote below)_
- **Schedule:** Schedule I _(verified: appears in its own passage below)_
- **Listed under:** Temporary listing of substances subject to emergency scheduling _(verified: appears in its own passage below)_
- **DEA code number:** 9674 _(verified: appears in the quote below)_
- **Temporary listing expires:** Aug. 26, 2028 _(verified: appears in its own passage below)_
- **CFR citation:** 21 CFR 1308.11(h)(91) _(our reading, not quoted from the source)_

## What the source says

> (91) Methyl (E)-2-((2S,3S,7aS,12aR,12bS)-3-ethyl-9-fluoro-7a-hydroxy-8- methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate (commonly known as MGM-16; also known as 9-fluoro-dihydro-7-hydroxymitragynine; or 10-fluoro-dihydro-7-hydroxymitragynine (depending on numbering convention)) including its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible. Since nomenclature of this substance is not internationally standardized, compounds of this structure, regardless of numerical designation of atomic positions are covered | 9674 |

## Where each value comes from

This source states these in separate places, so each value is shown with the passage that states it.

### Schedule

> § 1308.11 Schedule I.

### Listed under

> (h) Temporary listing of substances subject to emergency scheduling.

### Temporary listing expires

> adding paragraphs (h)(88) through (h)(91), effective Aug. 26, 2026 through Aug. 26, 2028

## Source

- https://www.ecfr.gov/current/title-21/chapter-II/part-1308

Last verified: 2026-09-01. Review by: 2026-12-30.
Part of [Federal controlled substance schedule (I-V) by drug, with DEA code number](https://referencesource.org/dea-controlled-substance-schedule-by-drug/).